This is a very interesting new study. LINK (abstract only)
“A transcriptional signature of “exercise resistance” in skeletal muscle of individuals with type 2 diabetes mellitus.” Metabolism. 2015 Sep;64(9):999-1004
“Exercise benefits most, but not all, individuals with type 2 diabetes mellitus (T2DM).”
“42 participants with T2DM from the previously reported HART-D study underwent a 9-month supervised exercise intervention.”
Conclusion: “These data suggest that a unique baseline expression pattern of genes involved in muscle fuel metabolism may predict an individual’s lack of exercise response in metabolic outcomes ”
This study did not look at whether any specific things could be done to change the muscle fuel metabolism pattern, and then see if such a change would result in the person changing to being a “responder” to exercise, instead of a non-responder.
It is worth wondering about this, because changing from a glucose-dominant metabolism to a ketosis-adapted metabolism will change the pattern of muscle fuel metabolism.
Note: T2DM is short for Type 2 Diabetes Mellitus