Brain Cancer and Metabolic Therapy

Review articles, 2015:

“The role of metabolic therapy in treating glioblastoma multiforme”

Surg Neurol Int. 2015; 6: 61. Published online 2015 Apr 16.  doi: 10.4103/2152-7806.155259  PMCID: PMC4405891
Joseph C. Maroon, Thomas N. Seyfried,1 Joseph P. Donohue, and Jeffrey Bost*

“By recognizing the underlying energy production requirements of cancer cells, newly proposed metabolic therapy is being used as an adjunct to standard GBM therapies. This review will discuss the calorie restricted ketogenic diet (CR-KD) as a promising potential adjunctive metabolic therapy for patients with GBMs. The effectiveness of the CR-KD is based on the “Warburg Effect” of cancer metabolism and the microenvironment of GBM tumors. We will review recent case reports, clinical studies, review articles, and animal model research using the CR-KD and explain the principles of the Warburg Effect as it relates to CR-KD and GBMs.”

Full Text LINK

The Efficacy of Ketogenic Diet and Associated Hypoglycemia as an Adjuvant Therapy for High-Grade Gliomas: A Review of the Literature

Published: February 27, 2015, Varshneya K, Carico C, Ortega A, et al. (2015-02-27 18:47:59 UTC) Cureus 7(2): e251. doi:10.7759/cureus.251  DOI: 10.7759/cureus.251

Extensive over-view of the topic, including good explanation of ketosis.

LINK to full text of article.

Professor Adrienne C. Scheck of the Barrow Brain Tumor Research Centre , from fall 2014

Dr. Scheck is also featured in this webinar:

Related to the program described by Dr. Scheck, the dietitian presents her experience and the protocol used in their research program:

This excellent presentation from fall 2014 reviews the program in practice at one U.S. hospital. They are conducting this as a research trial, so the protocol they use is very specific, so they can report on the outcome in a useful way.

In practice, a “ketogenic diet” is not one single exact protocol. It can be used with varying degrees of “strictness”, depending on the situation and the goals and what is considered worthwhile. Please do not be discouraged from the value of keto diets by thinking that they must involve a lot of time and preparation or that they are only useful if certain exacting details are met.

Basic Information Regarding Brain Tumors and Treatment Options

The above video is presented by The American Brain Tumor Association www.abta.orgFor further information regarding brain tumours, both malignant and not malignant (“benign” – which only refers to not malignant, does not mean “not harmful”):

  • their YouTube channel has over 100 educational videos.  LINK
  • there is extensive and updated info on their web site.

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